货车司机小文（李灿森饰）从深圳送货后回家，在与母亲一起吃饭时发生意外，平时温和善良的他竟突然狂性大发，活活将母亲砍死，被送入精神病院治疗，由于其病状奇特，医院邀请了著名灵学家杨牧师（谢君豪饰）为其驱魔，终于令小文恢复平静；与此同时，女学生阿YAN也出现同样情况，无故发狂，不停用刀自残，其家人无奈，只有将其捆绑于床上。电台DJ阿占（张智霖饰）所主持的节目收视率下降，他觉得阿YAN的离奇事件有可能刺激收视率，于是邀请杨牧师为其驱魔，并对整个过程进行现场拍摄，杨牧师费尽九牛二虎之力才将阿YAN体内的邪灵逐出，他还发现此邪灵与侵入小文体内的是同一灵体。
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