中年男子本（Noah Huntley 饰）的女儿莎拉（Skye Bennett 饰）身染重病，救治不愈。悲伤的本对医院失去信心，他决定带着莎拉离开这里。父女二人走进电梯，同乘的还有护士艾米莉（Dominique McElligott 饰）、医院保安瑞克（Leon Herbert 饰）、怀中抱着缠有绷带的玩具熊的男子约翰（William Hope 饰）以及一个精神失常的老人托比阿斯（Ronald Pickup 饰）。 电梯运行不久，突然发生故障。经过一段令人心焦的等待后，电梯最终停在了第六层。然而这层似乎有些奇怪，四周空空荡荡，悄无声息。正当众人疑惑不解的时候，危险悄悄向他们逼近……
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