厌倦了碌碌无为的平庸生活，德州女孩妮可·卡洛（詹米·亚历山大 Jaimie Alexander 饰）与男友杰西·希尔斯（乔伊·曼迪西诺 Joey Mendicino 饰）离家出走，驾车前往洛杉矶追寻她的表演梦想。两人一路前行，伴随着聊天、温存和争吵。期间他们迷路，汽油又所剩无几，好不容易才找到一个偏僻破旧的休息站。在使用过附近那昏暗、肮脏的洗手间后，妮可发现杰西和汽车竟然凭空消失。在这个收不到任何信号、杳无人烟仿佛与世隔绝的地带，她顿时陷入孤立无援的困境。 然而妮可的厄运并未就此结束，一辆神秘的黄色小卡车对她展开攻击，而各种各样离奇古怪的事件也相继发生……
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