飞扬跋扈的FBI特工莎拉（桑德拉·布洛克 Sandra Bullock 饰）总是料事如神，屡建奇功，然而她强悍孤高的工作态度却令很多同事受不了，怨声载道的状况又再次阻碍了她的升职，莎拉的上司决定将其派到波士顿，并安排了一名新搭档穆林斯（梅丽莎·麦卡西 Melissa McCarthy 饰），共同追捕一个俄罗斯毒品集团，一方面发挥莎拉的机智，一方面则是考验她是否拥有与人协作的能力。然而这位新搭档偏偏也不是省油的灯，而是波士顿一名特立独行满口脏话的女警察，两个从未合作过的彪悍女性，开始了令人捧腹的磨合期，然而她们通力合作追捕罪犯的好戏才刚刚开始……
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