这一天，汤姆正百无聊赖戏耍杰瑞解闷儿，突然门铃声响起。女主人前去看门，原来是她的朋友将三只嗷嗷待哺憨态可掬的小猫送来寄养。女主人充满爱心地将小猫接进屋内，并嘱咐汤姆好好照看他们。不久女主人外出购物，汤姆责无旁贷担起了保护小猫们的重任。谁知，这三只小猫长着天使的外表，却有恶魔一般的心。他们百般戏耍汤姆，用尽一切狡黠伎俩。一旁看热闹的杰瑞幸灾乐祸，没想到自己也惹火烧身，遭到小猫们的戏弄。 吃尽苦头的汤姆和杰瑞联合起来，决定好好教训这三只无法无天的小坏蛋。一场“大人”和“小鬼”的激烈较量就此展开……
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